Synthetic Ciguatoxins Selectively Activate Na(v)1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells

The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Na(v)1.2, Na(v)1.4, and Na(v)1.5) by accelerating activation kinetics and shifting the activation curve toward hyperpolarization (Yamaoka, K., Inoue, M., Miyahara, H., Miyazaki, K., and Hirama, M....

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Bibliografiske detaljer
Main Authors: Yamaoka, Kaoru, Inoue, Masayuki, Miyazaki, Keisuke, Hirama, Masahiro, Kondo, Chie, Kinoshita, Eiji, Miyoshi, Hiroshi, Seyama, Issei
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Membrane Transport, Structure, Function, and Biogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658054/
https://ncbi.nlm.nih.gov/pubmed/19164297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806481200
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