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PEP-19, an Intrinsically Disordered Regulator of Calmodulin Signaling

PEP-19 is a small calmodulin (CaM)-binding protein that greatly increases the rates of association and dissociation of Ca(2+) from the C-domain of CaM, an effect that is mediated by an acidic/IQ sequence in PEP-19. We show here using NMR that PEP-19 is an intrinsically disordered protein, but with r...

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Hlavní autoři: Kleerekoper, Quinn K., Putkey, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658041/
https://ncbi.nlm.nih.gov/pubmed/19106096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808067200
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