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Differences in Metabolite-mediated Toxicity of Tamoxifen in Rodents vs. Humans Elucidated with DNA/microsomes Electro-optical Arrays and Nanoreactors
Tamoxifen, a therapeutic and chemopreventive breast cancer drug, was chosen as a model compound because of acknowledged species specific toxicity differences. Emerging approaches utilizing electro-optical arrays and nanoreactors based on DNA/microsomes films were used to compare metabolite-mediated...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2657835/ https://ncbi.nlm.nih.gov/pubmed/19166339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx8004295 |
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