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Normal development and activation but altered cytokine production of Fyn-deficient CD4(+) T cells
The Src family kinase, Fyn, is expressed in T cells and has been shown to phosphorylate proteins involved in TCR signaling, cytoskeletal reorganization and IL-4 production. Fyn-deficient mice have greatly decreased numbers of NKT cells, and have thymocytes and T cells with compromised responses foll...
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主要な著者: | , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
2008
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2657555/ https://ncbi.nlm.nih.gov/pubmed/18832694 |
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