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Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production()

IL-1 has been shown to have strong mucosal adjuvant activities, but little is known about its mechanism of action. We vaccinated IL-1R1 bone marrow chimeric mice to determine if IL-1R1 expression on stromal cells or hematopoietic cells was sufficient for the maximal adjuvant activity of nasally deli...

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Detalhes bibliográficos
Main Authors: Thompson, Afton L., Johnson, Brandi T., Sempowski, Gregory D., Gunn, Michael D., Hou, Baidong, DeFranco, Anthony L., Staats, Herman F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293937/
https://ncbi.nlm.nih.gov/pubmed/22345651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100254
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