Effective induction of protective systemic immunity with nasally-administered vaccines adjuvanted with IL-1

IL-1α and IL-1β were evaluated for their ability to provide adjuvant activity for the induction of serum antibody responses when nasally-administered with protein antigens in mice and rabbits. In mice, intranasal (i.n.) immunization with pneumococcal surface protein A (PspA) or tetanus toxoid (TT) c...

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Hauptverfasser: Gwinn, William M., Kirwan, Shaun M., Wang, Sheena H., Ashcraft, Kathleen A., Sparks, Neil L., Doil, Catherine R., Tlusty, Tom G., Casey, Leslie S., Hollingshead, Susan K., Briles, David E., Dondero, Richard S., Hickey, Anthony J., Foster, W. Michael, Staats, Herman F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943532/
https://ncbi.nlm.nih.gov/pubmed/20723629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2010.08.006
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