The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer’s Disease

The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid β-peptide (Aβ) in Alzheimer’s Disease (AD). We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset...

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Bibliografski detalji
Glavni autori: Rogaeva, Ekaterina, Meng, Yan, Lee, Joseph H., Gu, Yongjun, Kawarai, Toshitaka, Zou, Fanggeng, Katayama, Taiichi, Baldwin, Clinton T., Cheng, Rong, Hasegawa, Hiroshi, Chen, Fusheng, Shibata, Nobuto, Lunetta, Kathryn L., Pardossi-Piquard, Raphaelle, Bohm, Christopher, Wakutani, Yosuke, Cupples, L. Adrienne, Cuenco, Karen T., Green, Robert C., Pinessi, Lorenzo, Rainero, Innocenzo, Sorbi, Sandro, Bruni, Amalia, Duara, Ranjan, Friedland, Robert P., Inzelberg, Rivka, Hampe, Wolfgang, Bujo, Hideaki, Song, YouQiang, Andersen, Olav, Willnow, Thomas E., Graff-Radford, Neill, Petersen, Ronald, Dickson, Dennis, Der, Sandy D., Fraser, Paul E., Schmitt-Ulms, Gerold, Younkin, Steven, Mayeux, Richard, Farrer, Lindsay A., St George-Hyslop, Peter
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657343/
https://ncbi.nlm.nih.gov/pubmed/17220890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1943
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