Prostaglandin D(2) inhibits interleukin-1β-induced matrix metalloproteinase-1 and -13 production by human osteoarthritic chondrocytes

OBJECTIVE: To investigate the effects of prostaglandin (PG) D(2) on interleukin-1β (IL-1)-induced matrix metalloproteinase (MMP)-1 and MMP-13 expression in human chondrocytes and the signalling pathways involved in the effects of PGD(2). METHODS: Chondrocytes were stimulated with IL-1 ± PGD(2) and M...

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Détails bibliographiques
Auteurs principaux: Zayed, Nadia, Afif, Hassan, Chabane, Nadir, Mfuna-Endam, Leandra, Benderdour, Mohamed, Martel-Pelletier, Johanne, Pelletier, Jean-Pierre, Motiani, Rajender K., Trebak, Mohamed, Duval, Nicolas, Fahmi, Hassan
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657141/
https://ncbi.nlm.nih.gov/pubmed/18975308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.23958
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