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Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

The efficiency of remyelination decreases with age, but the molecular mechanisms responsible for this decline remain only partially understood. In this study, we show that remyelination is regulated by age-dependent epigenetic control of gene expression. In demyelinated young brains, new myelin synt...

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Detalhes bibliográficos
Main Authors: Shen, Siming, Sandoval, Juan, Swiss, Victoria A, Li, Jiadong, Dupree, Jeff, Franklin, Robin J M, Casaccia-Bonnefil, Patrizia
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656679/
https://ncbi.nlm.nih.gov/pubmed/19160500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2172
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