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CONSERVED SEQUENCE IN THE AGGRECAN INTERGLOBULAR DOMAIN MODULATES CLEAVAGE BY ADAMTS-4 AND ADAMTS-5
BACKGROUND: Cleavage of aggrecan by ADAMTS proteinases at specific sites within highly conserved regions may be important to normal physiological enzyme functions, as well as pathological degradation. METHODS: To examine ADAMTS selectivity, we assayed ADAMTS-4 and -5 cleavage of recombinant bovine a...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2656578/ https://ncbi.nlm.nih.gov/pubmed/19101611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2008.11.008 |
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