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Design, Synthesis, and Biological Evaluation of N-Carboxyphenylpyrrole Derivatives as Potent HIV Fusion Inhibitors Targeting gp41

Based on the structures of small-molecule hits targeting the HIV-1 gp41, N-(4-carboxy-3-hydroxy)phenyl-2,5-dimethylpyrrole (2, NB-2) and N-(3-carboxy-4-chloro)phenylpyrrole (A(1), NB-64), 42 N-carboxyphenylpyrrole derivatives in two categories (A and B series) were designed and synthesized. We found...

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Bibliografiske detaljer
Main Authors: Liu, Kun, Lu, Hong, Hou, Ling, Qi, Zhi, Teixeira, Cátia, Barbault, Florent, Fan, Bo-Tao, Liu, Shuwen, Jiang, Shibo, Xie, Lan
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656571/
https://ncbi.nlm.nih.gov/pubmed/19053778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800869t
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