Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41

A new series of N-carboxyphenylpyrrole ligands were designed using GeometryFit based on an x-ray crystal structure of gp41. The synthesized ligands showed significant inhibitory activities against HIV gp41 6-helix bundle formation, HIV-1 mediated cell-cell fusion and HIV-1 replication.

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Bibliographic Details
Main Authors:	Wang, Yong, Lu, Hong, Zhu, Qiang, Jiang, Shibo, Liao, Yun
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2818531/ https://ncbi.nlm.nih.gov/pubmed/19932616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.10.139
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Structure-based design, synthesis and biological evaluation of new N-carboxyphenylpyrrole derivatives as HIV fusion inhibitors targeting gp41

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