Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol

The purpose of this study was to determine the intracellular trafficking and release pathways for the therapeutic protein, viral IL-10 (vIL-10), from transduced acinar epithelial cells from rabbit lacrimal gland. Primary cultured rabbit lacrimal gland acinar cells (LGACs) were transduced with adenov...

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Bibliographic Details
Main Authors: Xie, Jiansong, Marchelletta, Ronald R., Thomas, Padmaja B., Jacobs, Damon T., Yarber, Francie A., Cheney, Richard E., Hamm-Alvarez, Sarah F., Trousdale, Melvin D.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656410/
https://ncbi.nlm.nih.gov/pubmed/19056381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2008.10.023
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