Dominant negative PKCɛ impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini

Here we investigate the involvement of PKCɛ in apical actin remodeling in carbachol-stimulated exocytosis in reconstituted rabbit lacrimal acinar cells. Lacrimal acinar PKCɛ co-sedimented with actin filaments in an actin filament binding assay. Stimulation of acini with carbachol (100 μM, 2–15 min)...

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Hauptverfasser: Jerdeva, Galina V., Yarber, Francie A., Trousdale, Melvin D., Rhodes, Christopher J., Okamoto, Curtis T., Dartt, Darlene A., Hamm-Alvarez, Sarah F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1414898/
https://ncbi.nlm.nih.gov/pubmed/15930141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00546.2004
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