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Direct measurement of the full, sequence-dependent folding landscape of a nucleic acid

Nucleic acid hairpins provide a powerful model system for understanding macromolecular folding, with free energy landscapes that can be readily manipulated by changing the hairpin sequence. The full shapes of energy landscapes for the reversible folding of DNA hairpins under controlled loads exerted...

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Bibliografiske detaljer
Main Authors: Woodside, Michael T., Anthony, Peter C., Behnke-Parks, William M., Larizadeh, Kevan, Herschlag, Daniel, Block, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656380/
https://ncbi.nlm.nih.gov/pubmed/17095702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1133601
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