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Nanomechanical measurements of the sequence-dependent folding landscapes of single nucleic acid hairpins

Nucleic acid hairpins provide a powerful model system for probing the formation of secondary structure. We report a systematic study of the kinetics and thermodynamics of the folding transition for individual DNA hairpins of varying stem length, loop length, and stem GC content. Folding was induced...

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Detalhes bibliográficos
Main Authors: Woodside, Michael T., Behnke-Parks, William M., Larizadeh, Kevan, Travers, Kevin, Herschlag, Daniel, Block, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458853/
https://ncbi.nlm.nih.gov/pubmed/16606839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511048103
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