All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK(1/2 )pathway independently of RAR activation

INTRODUCTION: Interleukin-6 (IL-6) is thought to play a pathogenic role in rheumatoid arthritis and synovium is a major source of IL-6 release. We investigated the ability of retinoids to suppress IL-6 expression in IL-1-stimulated synovial fibroblasts, with special care to the contribution of retin...

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Détails bibliographiques
Auteurs principaux: Kirchmeyer, Mélanie, Koufany, Meriem, Sebillaud, Sylvie, Netter, Patrick, Jouzeau, Jean-Yves, Bianchi, Arnaud
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2008
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656246/
https://ncbi.nlm.nih.gov/pubmed/19068145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2569
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