Calcium Input Potentiates the Transforming Growth Factor (TGF)-β1-dependent Signaling to Promote the Export of Inorganic Pyrophosphate by Articular Chondrocyte

Transforming growth factor (TGF)-β1 stimulates extracellular PP(i) (ePP(i)) generation and promotes chondrocalcinosis, which also occurs secondary to hyperparathyroidism-induced hypercalcemia. We previously demonstrated that ANK was up-regulated by TGF-β1 activation of ERK1/2 and Ca(2+)-dependent pr...

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Bibliographische Detailangaben
Hauptverfasser: Cailotto, Frederic, Reboul, Pascal, Sebillaud, Sylvie, Netter, Patrick, Jouzeau, Jean-Yves, Bianchi, Arnaud
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103300/
https://ncbi.nlm.nih.gov/pubmed/21471198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.175448
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