Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)γ agonists on membrane-associated prostaglandin E(2 )synthase-1 in IL-1β-stimulated rat chondrocytes: evidence for PPARγ-independent inhibition by 15-deoxy-Δ(12,14)prostaglandin J(2)

Microsomal prostaglandin E synthase (mPGES)-1 is a newly identified inducible enzyme of the arachidonic acid cascade with a key function in prostaglandin (PG)E(2 )synthesis. We investigated the kinetics of inducible cyclo-oxygenase (COX)-2 and mPGES-1 expression with respect to the production of 6-k...

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Detalhes bibliográficos
Main Authors: Bianchi, Arnaud, Moulin, David, Sebillaud, Sylvie, Koufany, Meriem, Galteau, Marie-Madeleine, Netter, Patrick, Terlain, Bernard, Jouzeau, Jean-Yves
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1297580/
https://ncbi.nlm.nih.gov/pubmed/16277686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1830
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