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Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectories
The Src-family kinases are allosteric enzymes that play a key role in the regulation of cell growth and proliferation. In response to cellular signals, they undergo large conformational changes to switch between distinct inactive and active states. A computational strategy for characterizing the con...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2656156/ https://ncbi.nlm.nih.gov/pubmed/19225111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808261106 |
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