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The effect of the TRF2 N-terminal and TRFH regions on telomeric G-quadruplex structures

The sequence of human telomeric DNA consists of tandem repeats of 5′-d(TTAGGG)-3′. This guanine-rich DNA can form G-quadruplex secondary structures which may affect telomere maintenance. A current model for telomere protection by the telomere-binding protein, TRF2, involves the formation of a t-loop...

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Bibliografiske detaljer
Main Authors: Pedroso, Ilene M., Hayward, William, Fletcher, Terace M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655686/
https://ncbi.nlm.nih.gov/pubmed/19139067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1081
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