A Conserved Mechanism for Control of Human and Mouse Embryonic Stem Cell Pluripotency and Differentiation by Shp2 Tyrosine Phosphatase

Recent studies have suggested distinctive biological properties and signaling mechanisms between human and mouse embryonic stem cells (hESCs and mESCs). Herein we report that Shp2, a protein tyrosine phosphatase with two SH2 domains, has a conserved role in orchestration of intracellular signaling c...

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Detalhes bibliográficos
Main Authors: Wu, Dongmei, Pang, Yuhong, Ke, Yuehai, Yu, Jianxiu, He, Zhao, Tautz, Lutz, Mustelin, Tomas, Ding, Sheng, Huang, Ziwei, Feng, Gen-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655646/
https://ncbi.nlm.nih.gov/pubmed/19290061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004914
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