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Key Role for Activin B in Cellular Transformation after Loss of the von Hippel-Lindau Tumor Suppressor
The von Hippel-Lindau tumor suppressor gene (VHL) is mutated in clear cell renal cell carcinomas (RCC), leading to the activation of hypoxia-inducible factor (HIF)-mediated gene transcription. Several VHL/HIF targets, such as glycolysis, angiogenesis, cell growth, and chemotaxis of tumor cells, have...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2655617/ https://ncbi.nlm.nih.gov/pubmed/19158274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01184-07 |
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