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The increase in pulmonary arterial pressure caused by hypoxia depends on iron status
Hypoxia is a major cause of pulmonary hypertension. Gene expression activated by the transcription factor hypoxia-inducible factor (HIF) is central to this process. The oxygen-sensing iron-dependent dioxygenase enzymes that regulate HIF are highly sensitive to varying iron availability. It is unknow...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Science Inc
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2655431/ https://ncbi.nlm.nih.gov/pubmed/18955380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.160960 |
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