The increase in pulmonary arterial pressure caused by hypoxia depends on iron status

Hypoxia is a major cause of pulmonary hypertension. Gene expression activated by the transcription factor hypoxia-inducible factor (HIF) is central to this process. The oxygen-sensing iron-dependent dioxygenase enzymes that regulate HIF are highly sensitive to varying iron availability. It is unknow...

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Main Authors: Smith, Thomas G, Balanos, George M, Croft, Quentin P P, Talbot, Nick P, Dorrington, Keith L, Ratcliffe, Peter J, Robbins, Peter A
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2008
Assuntos:
Respiratory
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655431/
https://ncbi.nlm.nih.gov/pubmed/18955380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.160960
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