Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans

Hypoxia causes an increase in pulmonary artery pressure. Gene expression controlled by the hypoxia‐inducible factor (HIF) family of transcription factors plays an important role in the underlying pulmonary vascular responses. The hydroxylase enzymes that regulate HIF are highly sensitive to varying...

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Bibliographic Details
Published in:Physiol Rep
Main Authors: Talbot, Nick P., Croft, Quentin P., Curtis, M. Kate, Turner, Brandon E., Dorrington, Keith L., Robbins, Peter A., Smith, Thomas G.
Format: Artigo
Language:Inglês
Published: Wiley Periodicals, Inc. 2014
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4332205/
https://ncbi.nlm.nih.gov/pubmed/25501423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12220
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