A potential role for Akt/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle

Sepsis causes muscle atrophy and insulin resistance, but the underlying mechanisms are unclear. Therefore, the present study examined the effects of lipopolysaccharide (LPS)-induced endotoxaemia on the expression of Akt, Forkhead Box O (FOXO) and its downstream targets, to identify any associations...

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Detalhes bibliográficos
Main Authors: Crossland, Hannah, Constantin-Teodosiu, Dumitru, Gardiner, Sheila M, Constantin, Despina, Greenhaff, Paul L
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Integrative
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655379/
https://ncbi.nlm.nih.gov/pubmed/18818241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.160150
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