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Selecting Aptamers for a Glycoprotein through the Incorporation of the Boronic Acid Moiety
[Image: see text] The first general method for the selection of boronic acid-based aptamers that allow for glycan sub-structure focusing is described. Using fibrinogen as a model, we have selected boronic acid-modified DNA aptamers that have high affinities (low nM K(d)) and the ability to recognize...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2655352/ https://ncbi.nlm.nih.gov/pubmed/18763762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja801510d |
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