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Selecting Aptamers for a Glycoprotein through the Incorporation of the Boronic Acid Moiety

[Image: see text] The first general method for the selection of boronic acid-based aptamers that allow for glycan sub-structure focusing is described. Using fibrinogen as a model, we have selected boronic acid-modified DNA aptamers that have high affinities (low nM K(d)) and the ability to recognize...

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Autori principali: Li, Minyong, Lin, Na, Huang, Zhen, Du, Lupei, Altier, Craig, Fang, Hao, Wang, Binghe
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655352/
https://ncbi.nlm.nih.gov/pubmed/18763762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja801510d
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