Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase

High-throughput screening (HTS) is widely used in drug discovery. Especially for screens of unbiased libraries, false positives can dominate “hit lists”; their origins are much debated. Here we determine the mechanism of every active hit from a screen of 70,563 unbiased molecules against β-lactamase...

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Main Authors: Babaoglu, Kerim, Simeonov, Anton, Irwin, John J., Nelson, Michael E., Feng, Brian, Thomas, Craig J., Cancian, Laura, Costi, M. Paola, Maltby, David A., Jadhav, Ajit, Inglese, James, Austin, Christopher P., Shoichet, Brian K.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655312/
https://ncbi.nlm.nih.gov/pubmed/18333608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm701500e
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