Dynamic binding orientations direct activity of HIV reverse transcriptase

The reverse transcriptase of human immunodeficiency virus (HIV) catalyzes a series of reactions to convert the single-stranded RNA genome of HIV into double-stranded DNA for host-cell integration. This task requires the multifunctional reverse transcriptase to discriminate a variety of nucleic-acid...

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Main Authors: Abbondanzieri, Elio A., Bokinsky, Gregory, Rausch, Jason W., Zhang, Jennifer X., Le Grice, Stuart F. J., Zhuang, Xiaowei
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655135/
https://ncbi.nlm.nih.gov/pubmed/18464735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06941
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