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Characterization of a heparin-binding site on the catalytic domain of factor XIa: Mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor
Heparin accelerates inhibition of factor XIa (fXIa) by the serpins antithrombin (AT) and C1-inhibitor (C1-INH) by more than two orders of magnitude. The mechanism of the heparin-mediated acceleration of fXIa inhibition by these serpins is incompletely understood, as heparin appears to interact with...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654577/ https://ncbi.nlm.nih.gov/pubmed/19178150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802298r |
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