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Characterization of a heparin-binding site on the catalytic domain of factor XIa: Mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor

Heparin accelerates inhibition of factor XIa (fXIa) by the serpins antithrombin (AT) and C1-inhibitor (C1-INH) by more than two orders of magnitude. The mechanism of the heparin-mediated acceleration of fXIa inhibition by these serpins is incompletely understood, as heparin appears to interact with...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Yang, Likui, Sun, Mao-fu, Gailani, David, Rezaie, Alireza R.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2009
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654577/
https://ncbi.nlm.nih.gov/pubmed/19178150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802298r
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