The BARD1 C-Terminal Domain Structure and Interactions with Polyadenylation Factor CstF-50

[Image: see text] The BARD1 N-terminal RING domain binds BRCA1 while the BARD1 C-terminal ankyrin and tandem BRCT repeat domains bind CstF-50 to modulate mRNA processing and RNAP II stability in response to DNA damage. Here we characterize the BARD1 structural biochemistry responsible for CstF-50 bi...

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Bibliographic Details
Main Authors: Edwards, Ross A., Lee, Megan S., Tsutakawa, Susan E., Williams, R. Scott, Tainer, John A., Glover, J. N. Mark
Format: Artigo
Language:Inglês
Published: American Chemical Society 2008
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654182/
https://ncbi.nlm.nih.gov/pubmed/18842000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801115g
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