Blood Glucose Levels Regulate Pancreatic β-Cell Proliferation during Experimentally-Induced and Spontaneous Autoimmune Diabetes in Mice

BACKGROUND: Type 1 diabetes mellitus is caused by immune-mediated destruction of pancreatic β-cells leading to insulin deficiency, impaired intermediary metabolism, and elevated blood glucose concentrations. While at autoimmune diabetes onset a limited number of β-cells persist, the cells' rege...

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Bibliografische gegevens
Hoofdauteurs: Pechhold, Klaus, Koczwara, Kerstin, Zhu, Xiaolong, Harrison, Victor S., Walker, Greg, Lee, Janet, Harlan, David M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2009
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654100/
https://ncbi.nlm.nih.gov/pubmed/19287497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004827
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