Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS

Senescence is a potential tumor-suppressing mechanism and a commonly used model of cellular aging. One current hypothesis to explain senescence, based in part on the correlation of oxygen with senescence, postulates that it is caused by oxidative damage from reactive oxygen species (ROS). Here, we f...

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Autors principals: Klimova, Tatyana A., Bell, Eric L., Shroff, Emelyn H., Weinberg, Frank D., Snyder, Colleen M., Dimri, Goberdan P., Schumacker, Paul T., Budinger, G. R. Scott, Chandel, Navdeep S.
Format: Artigo
Idioma:Inglês
Publicat: The Federation of American Societies for Experimental Biology 2009
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653981/
https://ncbi.nlm.nih.gov/pubmed/18948382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-114256
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