Bradykinin Enhances AMPA and NMDA Receptor Activity in Spinal Cord Dorsal Horn Neurons by Activating Multiple Kinases to Produce Pain Hypersensitivity

Bradykinin potentiates synaptic glutamate release and action in the spinal cord via presynaptic and postsynaptic B(2) receptors, contributing thereby to activity-dependent central sensitization and pain hypersensitivity (Wang et al., 2005). We have now examined the signaling pathways that are respon...

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Autors principals: Kohno, Tatsuro, Wang, Haibin, Amaya, Fumimasa, Brenner, Gary J., Cheng, Jen-Kun, Ji, Ru-Rong, Woolf, Clifford J.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2008
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653863/
https://ncbi.nlm.nih.gov/pubmed/18434532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5349-07.2008
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