Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation

We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted...

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Detalhes bibliográficos
Main Authors: Lopergolo, A, Pennati, M, Gandellini, P, Orlotti, N I, Poma, P, Daidone, M G, Folini, M, Zaffaroni, N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653776/
https://ncbi.nlm.nih.gov/pubmed/19223905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604927
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