Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3

BACKGROUND & AIMS: Celiac disease is an immune-mediated enteropathy triggered by gliadin, a component of the grain protein gluten. Gliadin induces an MyD88-dependent zonulin release that leads to increased intestinal permeability, a postulated early element in the pathogenesis of celiac disease....

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Auteurs principaux: Lammers, Karen M., Lu, Ruliang, Brownley, Julie, Lu, Bao, Gerard, Craig, Thomas, Karen, Rallabhandi, Prasad, Shea-Donohue, Terez, Tamiz, Amir, Alkan, Sefik, Netzel-Arnett, Sarah, Antalis, Toni, Vogel, Stefanie N., Fasano, Alessio
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653457/
https://ncbi.nlm.nih.gov/pubmed/18485912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.03.023
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