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Ligand Tuning in Asymmetric Hydrovinylation of 1,3-Dienes. A Stereoselective Route to either Steroid-C(20) (S) or -C(20) (R) Derivatives
1,3-Dienes derived from steroidal D-ring C(17)-ketones undergo Ni(II)-catalyzed hydrovinylation to give 1,2- or 1,4-addition of ethylene. Using finely tuned phosphoramidite ligands it is possible to synthesize either the C(20) (R)- or the C(20) (S)-derivatives without mutual contamination. The propo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652850/ https://ncbi.nlm.nih.gov/pubmed/18570419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja711475f |
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