Anionic Amino Acids near the Pro-α-defensin N Terminus Mediate Inhibition of Bactericidal Activity in Mouse Pro-cryptdin-4

In mouse Paneth cells, α-defensins, termed cryptdins (Crps), are activated by matrix metalloproteinase-7-mediated proteolysis of inactive precursors (pro-Crps) to bactericidal forms. The activating cleavage step at Ser(43) ↓ Ile(44) in mouse pro-Crp4-(20–92) removes nine acidic amino acids that coll...

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Hauptverfasser: Figueredo, Sharel M., Weeks, Colby S., Young, Steven K., Ouellette, André J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652335/
https://ncbi.nlm.nih.gov/pubmed/19106102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807024200
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