Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 Residue

Because the influenza A virus has an RNA genome, its RNA-dependent RNA polymerase, comprising the PA, PB1, and PB2 subunits, is essential for viral transcription and replication. The binding of RNA primers/promoters to the polymerases is an initiation step in viral transcription. In our current stud...

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Autores principales: Kuzuhara, Takashi, Kise, Daisuke, Yoshida, Hiroko, Horita, Takahiro, Murazaki, Yoshimi, Nishimura, Akie, Echigo, Noriko, Utsunomiya, Hiroko, Tsuge, Hideaki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652293/
https://ncbi.nlm.nih.gov/pubmed/19144639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C800224200
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