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Curvature Dynamics of α-Synuclein Familial Parkinson Disease Mutants: MOLECULAR SIMULATIONS OF THE MICELLE- AND BILAYER-BOUND FORMS
α-Synuclein remains a protein of interest due to its propensity to form fibrillar aggregates in neurodegenerative disease and its putative function in synaptic vesicle regulation. Herein, we present a series of atomistic molecular dynamics simulations of wild-type α-synuclein and three Parkinson dis...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652287/ https://ncbi.nlm.nih.gov/pubmed/19126542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808895200 |
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