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Defining the Binding Site of Levosimendan and Its Analogues in a Regulatory Cardiac Troponin C−Troponin I Complex

[Image: see text] The interaction of Cardiac Troponin C (cTnC) and Cardiac Troponin I (cTnI) plays a critical role in transmitting the Ca(2+) signal to the other myofilament proteins in the activation of cardiac muscle contraction. As such, the cTnC−cTnI interface is a logical target for cardiotonic...

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Autori principali: Robertson, Ian M., Baryshnikova, Olga K., Li, Monica X., Sykes, Brian D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2008
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652250/
https://ncbi.nlm.nih.gov/pubmed/18570382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800438k
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