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Formation of DNA−Protein Cross-Links Between γ-Hydroxypropanodeoxyguanosine and EcoRI
[Image: see text] The toxicity of acrolein, an α,β-unsaturated aldehyde produced during lipid peroxidation, is attributable to its high reactivity toward DNA and cellular proteins. The major acrolein−DNA adduct, γ-hydroxypropano-2′-deoxyguanosine (γ-HOPdG), ring opens to form a reactive N(2)-oxoprop...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651693/ https://ncbi.nlm.nih.gov/pubmed/18690724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx800092g |
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