Structural adaptations in the interaction of EcoRI endonuclease with methylated GAATTC sites.

We have studied the interaction of EcoRI endonuclease with oligonucleotides containing GAATTC sites bearing one or two adenine-N6-methyl groups, which would be in steric conflict with key protein side chains involved in recognition and/or catalysis in the canonical complex. Single-strand methylation...

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Bibliographic Details
Main Authors: Jen-Jacobson, L, Engler, L E, Lesser, D R, Kurpiewski, M R, Yee, C, McVerry, B
Format: Artigo
Language:Inglês
Published: 1996
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC450225/
https://ncbi.nlm.nih.gov/pubmed/8654385
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