Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

Here, we describe an N-ethyl-N-nitrosourea (ENU)-induced missense error in the membrane-bound transcription factor peptidase site 1 (S1P)-encoding gene (Mbtps1) that causes enhanced susceptibility to dextran sodium sulfate (DSS)-induced colitis. S1P cleaves and activates cAMP response element bindin...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Brandl, Katharina, Rutschmann, Sophie, Li, Xiaohong, Du, Xin, Xiao, Nengming, Schnabl, Bernd, Brenner, David A., Beutler, Bruce
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651297/
https://ncbi.nlm.nih.gov/pubmed/19202076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813036106
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky