Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

Here, we describe an N-ethyl-N-nitrosourea (ENU)-induced missense error in the membrane-bound transcription factor peptidase site 1 (S1P)-encoding gene (Mbtps1) that causes enhanced susceptibility to dextran sodium sulfate (DSS)-induced colitis. S1P cleaves and activates cAMP response element bindin...

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Bibliographic Details
Main Authors: Brandl, Katharina, Rutschmann, Sophie, Li, Xiaohong, Du, Xin, Xiao, Nengming, Schnabl, Bernd, Brenner, David A., Beutler, Bruce
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651297/
https://ncbi.nlm.nih.gov/pubmed/19202076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813036106
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