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The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology

The aryl hydrocarbon receptor (AHR) plays a central role in 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) hepatotoxicity, regulation of xenobiotic metabolism, and hepatovascular development. Each of these processes appears to be dependent on binding of the AHR to dioxin- responsive elements (DREs) wi...

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Detalles Bibliográficos
Main Authors: Nukaya, Manabu, Moran, Susan, Bradfield, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651201/
https://ncbi.nlm.nih.gov/pubmed/19261855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809613106
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