The Aryl Hydrocarbon Receptor-interacting Protein (AIP) Is Required for Dioxin-induced Hepatotoxicity but Not for the Induction of the Cyp1a1 and Cyp1a2 Genes

The aryl hydrocarbon receptor (AHR) plays an essential role in the toxic response to environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), in the adaptive up-regulation of xenobiotic metabolizing enzymes, and in hepatic vascular development. In our model of AHR signaling, th...

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Main Authors: Nukaya, Manabu, Lin, Bernice C., Glover, Edward, Moran, Susan M., Kennedy, Gregory D., Bradfield, Christopher A.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2010
主題:
Gene Regulation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975184/
https://ncbi.nlm.nih.gov/pubmed/20829355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.132043
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