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Computing Highly Correlated Positions Using Mutual Information and Graph Theory for G Protein-Coupled Receptors

G protein-coupled receptors (GPCRs) are a superfamily of seven transmembrane-spanning proteins involved in a wide array of physiological functions and are the most common targets of pharmaceuticals. This study aims to identify a cohort or clique of positions that share high mutual information. Using...

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Detalhes bibliográficos
Main Authors: Fatakia, Sarosh N., Costanzi, Stefano, Chow, Carson C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650788/
https://ncbi.nlm.nih.gov/pubmed/19262747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004681
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