Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo

High levels of expression of the human DEK gene have been correlated with numerous human malignancies. Intracellular DEK functions have been described in vitro and include DNA supercoiling, DNA replication, RNA splicing, and transcription. We have demonstrated DEK also suppresses cellular senescence...

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Hauptverfasser: Wise-Draper, Trisha M., Mintz-Cole, Rachael A., Morris, Teresa A., Simpson, David S., Wikenheiser-Brokamp, Kathryn A., Currier, Mark A., Cripe, Timothy P., Grosveld, Gerard C., Wells, Susanne I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650744/
https://ncbi.nlm.nih.gov/pubmed/19223548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2304
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